Susceptibility-Associated Major Histocompatibility Complex (MHC) Haplotype in Severe Puumala Hantavirus Infection

This panel presented data on host genes that influence susceptibility to or manifestations of four infectious diseases: Puumala hantavirus infection, tuberculosis (TB), Lyme disease, and AIDS. Gus Birkhead, Council of State and Territorial Epidemiologists, introduced the session, highlighting its timeliness in relation to the rapidly emerging body of data on our 100,000 human genes that stems from the Human Genome and related projects. The presentations introduced several approaches to identifying a host gene–infectious disease interaction. Panelists presented casecontrol studies of hantavirus infection, AIDS, TB, and Lyme disease that used the candidate gene approach; the new approach, genome scanning by microsatellites to identify genes associated with TB susceptibility, was also described. Candidate genes were chosen on the basis of pathology of the infectious disease (human leukocyte antigen [HLA], tumor necrosis factor [TNF], the antigen processing [TAP]), mouse genetic studies of the pathogen (NRAMP1 in TB), or epidemiologic findings of disease severity (Vitamin D and TB).